Malaria: The facts for determining good practice
RCN Travel Health Forum and the British Travel Health Association Joint Conference and Exhibition
Monday 8 December 2008
Conference summary by JANE POWELL, GlaxoSmithKline (GSK) Travel Health. The conference and exhibition were wholly sponsored by GSK and Jane attended in her role as Brand Manager.
- Malaria in travellers: Continuing public education is key to prevention
- VFRs are key targets in the fight against malaria
- Fifth malaria variation emerging in European travellers
- ABCD: Still at the heart of malaria education
In early December the RCN Travel Health Forum (THF) and the British Travel Health Association (BTHA) held a joint conference dedicated to the prevention of malaria. It may have been a cold winter morning in London, but the delegates were undaunted in their quest to learn more about this tropical disease and, with 140 attendees and experts in the field sharing their knowledge, the house was full.
Opening address
Following the THF Chair Sandra Grieve's opening remarks, Dr Peter Carter OBE, Chief Executive & General Secretary of the RCN, welcomed delegates to the study day and spoke about the current period of changes and challenges the THF was experiencing. This was mainly due to the merger with four other RCN forums uniting to form a Public Health Forum and the ever-changing global threat of infectious diseases, exemplified by the recent cholera outbreak in Zimbabwe. Dr Carter highlighted that there was a clear need for educational initiatives and further study days to support nurses during this challenging period.
Information and resources on malaria
The first speaker of the day was Jane Chiodini, Travel Health Specialist Nurse, who had succumbed to a winter virus and had effectively lost her voice. She proceeded stoically and came prepared, presenting her slides with speech bubbles against the background music of The Tremeloes hit Silence is Golden. However, what her presentation lacked in volume, it certainly made up for in content. She provided attendees with a valuable overview of the resources available nationally and internationally on malaria prevention, including:
- Health Protection Agency (HPA) Malaria Reference Laboratory, guidelines and regular updates on malaria epidemiology reporting, for example, recent increased incidence of malaria in the Gambia
- The World Health Organization (WHO) website and its new Malaria Report (available at www.who.int/malaria)
Other websites such as:
- Centers for Disease Control and Prevention (Atlanta)
- Health Protection Scotland's Travax for health professionals and Fit-for-Travel for the general public
- The National Travel Health Network and Centre (NaTHNaC)
- Malaria Hotspots
Educational materials:
- The third edition of the Wellcome Trust's CD available from: www.malaria.wellcome.ac.uk
- A new malaria educational resource called Malaria matters: best practice in malaria prevention. It is an RCN-accredited training initiative developed by Jane Chiodini, and produced and funded by GSK. It includes a number of features such as animations, case studies and best practice consultation video clips. For more information or for a copy, call the Virgo HEALTH press office on 020 8939 2479.
Jane Chiodini also underlined the importance of referring to these and similar resources regularly in order to stay abreast of travel health developments, such as the newly emerging malaria strain in humans called Plasmodium knowlesi.
Knowledge, attitudes and practices of African visiting friends and relatives (VFRs)
Penny Neave, Health Protection Specialist and Health Strategist at the HPA, explored the challenges associated with offering travel health advice to VFRs - a notoriously difficult sector of the population to reach and treat who:
- are mostly based in London, in areas such as Southwark
- may not present for malaria advice believing they already have immunity
- typically do not adhere to the "ABCD" of protection
- may not stick to their antimalarials for a number of reasons, including a belief that prophylactics challenge their African heritage
- perceive malaria as being less serious than typhoid; malaria is viewed as a flu-like illness and it is also confused with a simple fever
- may not present for treatment as they fear being isolated in hospital
- accounted for approximately two-thirds of imported malaria cases last year (the majority of which came from West Africa, with other cases from countries such as Uganda and Sierra Leone).
Penny explained that reluctance to take antimalarials has led to VFR men being twice as likely to die from malaria infection as women and reiterated the importance of recommending chemoprophylaxis: about half of the fatal cases of imported malaria occur in travellers who had taken no chemoprophylaxis.
Ultimately, it is important to remember when working with Africans or African VFRs that this group is not homogenous. Indeed, wide-ranging cultural preferences and socioeconomic factors will shape behaviour of each traveller.
Grappling with mosquitoes!
In the next session, Dr Nigel Hill, an entomologist from the London School of Hygiene and Tropical Medicine, assessed bite prevention methods available for travellers. He emphasised that they should be evaluated in terms of suitability in different circumstances and efficacy, recommending:
- insecticide sprays (containing DEET)
- coils - cheap and relatively effective
- vaporisers - can be highly effective
- sprays - which interfere with mosquitoes' navigational sensors
- nets - an article in the BMJ showed an 80 per cent reduction in malaria in patients using nets.*
Dr Hill then briefly discussed the methods that he wouldn't recommend to travellers because they have been shown to be ineffective, including:
- buzzers
- vitamin B1 supplements
- foods such as chilli or garlic.
Malaria in returning travellers
In the final morning session, Dr Nick Beeching, Senior Lecturer and Clinical Lead in Infectious Diseases from the Liverpool School of Tropical Medicine, reviewed the latest trends in imported malaria rates. In particular, he highlighted that, although initially it was thought that incidence would decline from the 1950s onwards, malaria is currently resurgent.
Dr Beeching explained that the biggest problems preventing the successful treatment of malaria cases are delays in presentation and delays in diagnosis and treatment. For instance, he recalled three deaths from malaria in Liverpool that were caused by delays in diagnosis. A history of travel should always be recorded, and doctors and nurses investigating illness in travellers returning from malaria endemic regions should always consider malaria as a possible diagnosis until it can be excluded.
With regards to the treatment of malaria infection, Dr Beeching urged delegates to:
- identify what stage the disease is at: blood stage or liver stage
- remember malaria can still be present one-to-two years after travel
- refer to the algorithm available from www.britishinfectionsociety.org for further information.
One of the most recent and important developments that Dr Beeching discussed was the identification of Plasmodium knowlesi, a new form of malaria originally found in monkey hosts, but now recognised to cause disease in humans. It is prevalent in Thailand and Malaysia, and is now emerging in travellers returning from these areas to Europe.
Case scenarios and Q&A session
Following lunch and an opportunity to visit the exhibition where various resources available to the delegates were demonstrated, Dr Nick Beeching chaired a panel discussion and interactive session with Diane Parsons, Senior Nurse at InterHealth, representing the THF and Claire Wong, Travel Health Nurse Specialist from NaTHNaC, representing the BTHA. They considered case studies of travellers visiting four at-risk areas (Goa, Guinea, the Caribbean and South America), which illustrated that:
- The prevalence of malaria can vary within a given geographical area. Therefore travel health professionals need to maintain an up-to-date knowledge of at-risk areas.
- It is important to highlight the additional risks malaria poses to women who are pregnant or breastfeeding. It is also advisable for them to find out about health provisions available at their destination.
- Not all areas of at-risk countries require prophylaxis so it is important to determine exactly where travellers are visiting.
- Different antimalarials are recommended for different areas and an appropriate drug must be selected that will protect the patient for the entire trip - that is, one that will not require them to switch halfway through their travels should they have a multi-destination itinerary.
I'll never get malaria
Tim Beacon, Director of the Outdoor Experience, emphasised the importance of assessing travellers' risk of exposure to malaria during adventure travel and that awareness and preparation were crucial for prevention. He reiterated the importance of:
- communicating effectively with travellers to advise them on malaria prophylaxis, using plain language at all times. He advised that using complicated medical terminology caused the traveller to switch off, resulting in the rest of the advice given in a consultation being forgotten
- following the four key steps for malaria prevention:
Awareness
Bite prevention
Chemoprophylaxis
Diagnosis.
When he was a young traveller, Tim recalled, vital information regarding malaria prevention was unavailable. This led to many of his friends contracting malaria because they were unaware of the risks. Today, he said, there was no excuse for travellers to be unaware of malaria and how to prevent it, but he still thought there was a need for education.
The role of pharmacists in malaria advice
In the following session, Professor Larry Goodyer, Head of the School of Pharmacy at De Montfort University, described the current provision of travel health advice - especially on malaria - as delivered by community pharmacists. He explored the role pharmacists can play in advising travellers on malaria prevention, including:
- the changing role of pharmacy as a provider of services within the NHS. For example, they currently provide advice on bite prevention and antimalarial prophylaxis, either supplying chloroquine and proguanil or referring to medical and nursing colleagues for prescription only products; however, pharmacists are becoming non-medical prescribers.
- the scope for establishing travel clinics in community pharmacies, led either by pharmacists or nurses.
Malaria: advice for children and young people
The final session of the day saw Dr Delane Shingadia, a consultant in paediatric infectious diseases at London's Great Ormond Street Hospital, discussing the challenges faced in the prevention of malaria in children and young people. In particular, he focused on the following points:
- Most malaria in children occurs in VFRs, who often consume local produce or water and stay in rural areas without equipment for bite prevention.
- VFRs should be targeted by health care professionals to ensure that they receive accurate information and use preventative measures.
- Many parents may wrongly believe they have "natural immunity" and also that this immunity is transferred to their children.
- The importance of prescribing appropriately in children: less than half take prophylaxis and only a third of this is appropriate for the areas to which they are travelling.
- Parents need to be alerted to seek prompt treatment for their children if they are ill on return from a malaria endemic area.
Dr Shingadia went on to acknowledge that the source of pre-travel advice in VFR populations is often not clear, with risk factors associated with this group different to the general population. Often VFRs will travel to at-risk areas while pregnant, with children or while unwell with multiple other illnesses. They also frequently arrange travel at the last minute with little time to seek professional advice - and many simply don't ask for advice at all.
At the close of the meeting Dr John Davies, Chair of the BTHA, and Sandra Grieve underlined that malaria is a preventable disease that should be at the forefront of travel health advice for people visiting endemic regions of the world. The high turnout for the event illustrated the desire for up-to-date knowledge as well as the importance of continuing education and sharing best practice in travel health.
*Hill N, Lenglet A et al. (2007) "Plant based insect repellent and insecticide treated bed nets to protect against malaria in areas of early evening biting vectors: double blind randomised placebo controlled clinical trial in the Bolivian Amazon", BMJ 2007;335(7628):1023.

