47. Fatigue in gynaecological cancer patients: A prospective longitudinal survey

Gillian Prue, Research Associate, Institute of Nursing Research, University of Ulster, Newtownabbey, Northern Ireland, United Kingdom
Co authors: Jane Rankin, James Allen, Jacqueline Gracey & Fiona Cramp
ge.prue@ulster.ac.uk

Abstract:

Background:

Gynaecological cancer has received nominal attention in the area of cancer-related fatigue (CRF) (Olt 2003). It has been reported that this population experience worse fatigue than individuals with other cancers (Payne 2002). Aims: The aims of this survey were to analyse the fatigue experienced over 12 months by a gynaecological cancer population, to determine if the fatigue was more severe than that reported by non-cancer females, and to explore the variables associated with CRF.

Methods:

A prospective longitudinal survey was implemented involving gynaecological cancer patients from three cancer centres, and age matched females with no cancer history. Data was collected over a 12 month period during and after anti-cancer treatment. Fatigue was assessed using the Multidimensional Fatigue Symptom Inventory-Short Form.

Results:

From February 2005 to February 2006 a convenience sample of sixty-five cancer patients (mean age = 57.4, SD 13.9) and 60 non-cancer subjects (mean age 55.4, SD 13.6) participated. Sample size was justified through an interim analysis. General Linear Modelling (GLM) indicated that females with cancer had significantly worse fatigue than non-cancer females at all time points (p = 0.00) and that the level of CRF changed with time (p = 0.02). Psychological distress was the only independent predictor of CRF during treatment (p = 0.00), explaining 44% of the variance in fatigue. After treatment, psychological distress (p = 0.00) and physical symptom distress (p = 0.03) were independent predictors of fatigue (81% of the variance).

Discussion:

Individuals with gynaecological cancer experience significantly worse fatigue than cancer-free women during treatment, and this raised fatigue persists after treatment.

Conclusion:

Healthcare professionals should screen individuals with gynaecological cancer regularly for fatigue and provide reassurance that persistent fatigue is not indicative of disease progression. These findings signify a need for research regarding the management of CRF in women with gynaecological cancer.

Biography:

Gillian Prue graduated from the University of Ulster in June 2003 with a first class honours degree in Physiotherapy. Through her interest in supportive care in cancer, she commenced a PhD in October 2003 at the University of Ulster in the area of cancer-related fatigue (CRF). This research has focused on determining the prevalence and pattern of CRF and identifying the factors associated with its development. It is hoped that the findings of this research will aid the development of effective strategies for the non-pharmacological management of the condition. Through her PhD work, Gillian has published in cancer journals and presented at both national and international conferences. In June 2006, Gillian took up a Research Associate post at the University of Ulster, continuing her supportive care in cancer research work.